Although babies with PVL generally have no outward signs or
symptoms of the disorder, they are at risk for motor disorders
(especially of the lower limbs), delayed mental development,
coordination problems, and vision and hearing impairments.
Children with PVL have higher levels of
optic nerve hypoplasia
PVL may be accompanied by a hemorrhage or bleeding in the
periventricular-intraventricular area (the area around and
inside the ventricles), and can lead to
disorder can be diagnosed by
magnetic resonance imaging
of the head is diagnostically more accurate.
when administered post-insult
is considered to be protective against selective
white matter injury and decreases the subsequent neuromotor
receptor-mediated cell death and
influx, as well as
currents in developing
Children with PVL should receive regular medical screenings to
determine appropriate interventions.
The prognosis for individuals with PVL depends
upon the severity of the brain damage. Some children exhibit
fairly mild symptoms, while others have significant deficits and